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Bormioli Pharma materials

The Bormioli Pharma offering includes a range of pharmaceutical containers with characteristics that fully meet the delicate brief of preserving medicines.

Production is based on the use of several types of materials having different physical-organoleptic characteristics; the choice of materials is carried out by following the criterion of best achievable results in relation to the customer’s particular needs.

Glass

The main characteristic of the glass is its chemical stability, which differs depending on the product that the glass comes into contact with according to its use. In this respect the different types of glass are manufactured in full compliance with standards imposed by the European Pharmacopoeia (EP) and United States Pharmacopeia (USP).

  • Neutral type I glass

Bormioli type I is a borosilicate glass, characterized by high hydrolytic stability. This type of glass is ideal for holding all types of injectable products with an acidic, neutral or mildly alkaline pH.

These containers may be sterilised before and after filling and offer better mechanical resistance to large differences in temperature compared to type II and III glass.
  • Type II glass – USP and FE

Bormioli type II is a sodium-calcium glass which, with proper treatment of the surfaces, achieves the hydrolytic stability of type I glass. Type II containers are suited to packaging for injectable and non-injectable preparations in acidic or neutral solution.

 

  • Type III glass

Bormioli type III is a sodium-calcium glass with low alkaline content and high hydrolytic resistance.

Results for hydrolytic resistance and resistance to sudden temperature changes are better than for normal glass, but inferior to borosilicate glass.

Type III glass is suited to non-aqueous or powder injectable preparations, excluding freeze-dried medicines. It can also be used for non-parental preparations.

Type III glass containers are normally dry sterilized before being filled.

  • Yellow Amber Glass

The use of yellow amber glass is recommended by European and United States pharmaceutical standards for preparations sensitive to ultraviolet rays.

Adding colouring oxide agents enables this type of glass to protect contents while maintaining high transparency.

Plastics

For over 40 years, Bormioli Pharma has been using the principal plastic resins, including PET, PP, PE, PEN in order to provide the market with quality packaging.

All the plastic materials used by Bormioli Pharma undergo a careful and scrupulous type-approval procedure; they are suitable for contact with food and, in most cases, are in conformity with the specifically related information found in European Pharmacopoeia.

Plastic materials used by Bormioli Pharma are recyclable and ideal for thermal destruction and energy recovery.

  • Autoclavable PP

PP withstands the sterilization process in autoclave without undergoing decomposition or loss of performance.

  • Barrier PET

The barrier PET allowed enhancing the oxygen-barrier properties of PET bottles while maintaining a good transparency.

They are food grade materials in compliance with European countries and US FDA standards, besides having received the approval by the European Pharmacopoeia Monograph 3.2.2.. They have also passed tests on global migration, thus resulting chemically inert.

  • Barrier PE

PE Barrier is an additive that makes it possible to increase the humidity barrier properties of standard HDPE by up to 30%-35%. This is a passive barrier material against water vapor (humidity), which is therefore particularly suitable for packaging damp-sensitive products (tablets).

  • High transparency PP

This material offers great transparency, outstanding mechanical properties and is also certified "phtaletes free", offering a further guarantee of safety for patients.

  • COC/COP

Transparent, pure and unbreakable, the COC/COP bottles provides an excellent barrier against humidity and therefore maintains content integrity.

These containers answer the need to preserve delicate pharmaceutical products, thanks to their elevated chemical stability and the fact that they can be sterilized by autoclave and gamma rays.

COC/COP are also conforms to American, European and Japanese pharmacopoeia.

  • PEN

PEN provides excellent performance in terms of barrier, in particular, to water vapour, it is more resistant under hot-fill conditions and it offers a better response to sterilization than PET.

Moreover, unlike other polymers, it maintains the transparency properties of glass containers.

PEN bottles can be used as packages for valuable pharmaceutical products or products requiring careful handling, such as anesthetics, which demand excellent mechanical and chemical properties with the plus of infrangibility.

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